The first person to receive a heart transplant from a genetically modified pig has died two months after the medical milestone, the hospital that carried out the surgery said Wednesday.
WASHINGTON, United States — The procedure raised hopes that advances in cross-species organ donation could one day solve the chronic shortage of human organs available for donation, and the team behind the operation say they are “optimistic” about its future success.
Muhammad Mohiuddin, director of the university’s cardiac xenotransplantation program, did however say in a video statement that Bennett was having “infectious episodes.” Following surgery, the transplanted heart had performed very well for several weeks without any signs of rejection, the hospital added.
Mohiuddin said that the team had “gained invaluable insights” from the experience, adding: “We remain optimistic and plan on continuing our work in future clinical trials.” To meet demand, doctors have long been interested in so-called xenotransplantation, or cross-species organ donation, with experiments tracing back to the 17th century.
Pigs make for ideal donors because their organ size is similar to that of humans, they grow rapidly and have large litters. They are also already raised as a food source, so there is less controversy surrounding their organs’ use compared to primates’.Three genes that would have led to rejection of pig organs by humans were “knocked out,” as was a gene that would have led to excessive growth of pig heart tissue.
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