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Biologists from the University of the Philippines Diliman have developed a mathematical model that can detect lymphovascular invasion , an early indicator of metastasis, in breast cancer patients even before a surgical operation. “If we can detect LVI earlier, doctors could personalize patient treatment and improve their outcomes.
The scientists found that certain genes involved in breaking down anti-cancer drugs, called the UGT1 and CYP genes, are more abundant in patients with LVI. Hence, the drugs are becoming less effective because they are easily broken down. “An elastic net regression model containing 13 of these uridine 5'-diphospho-glucuronosyltransferases and cytochrome P450 genes can predict LVI status with 92% accuracy,” the abstract read.
University Of The Philippines Biologists Science Research
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