People with two copies of a risk gene have genetic form of Alzheimer's, scientists say

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People with two copies of a risk gene have genetic form of Alzheimer's, scientists say
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CHICAGO - People who carry two copies of the APOE4 gene are virtually guaranteed to develop Alzheimer's and face symptoms at an earlier age, researchers reported on Monday in a study that could redefine such carriers as having a new genetic form of the mind-wasting disease.The reclassification could change Alzheimer's research, diagnosis and approaches to treatment, according to the researchers, whose study was published in the journal Nature Medicine.

"This study adds compelling data to suggest that people with two copies of this gene are almost guaranteed to develop Alzheimer’s if they live long enough, and that they will develop Alzheimer’s earlier than people without this gene," said professor Tara Spires-Jones, an Alzheimer's researcher at the University of Edinburgh who was not involved in the study.

Nearly all APOE4 homozygotes in the study had higher levels of amyloid at age 65 than people who did not carry the risk variant. "No matter how many of APOE4 one carries the underlying disease processes seem similar across cases of Alzheimer's disease," he said.

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