There is little evidence that most antidepressants are effective against chronic pain, the largest study conducted on the subject said. | AFP
So antidepressants are often prescribed for chronic pain patients in the hope that the chemicals in the brain that affect mood could also impact pain.
Scientists from several UK universities looked at 176 trials that included nearly 30,000 patients who took 25 different antidepressants for their chronic pain. While it was equally effective for fibromyalgia as well as musculoskeletal and nerve pain, the researchers said there was a lack of data on long-term side effects.
Because one in three people with chronic pain reports a positive response to placebos, it was likely doctors had heard glowing reviews of the drug from their patients, she told an online press conference.
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