We know that our bodies aren’t defenseless against other pathogens after we get COVID.
”). Their top-line results are often circulated as validation of widespread and ongoing immune dysregulation. But that’s not really true.
To understand why these studies aren’t validation requires going a bit in the methodological weeds. In most of them, researchers take a group of patients who suffered from COVID—often a mix of mild, moderate, and severe cases—and find a group of “matched controls,” or uninfected people with similar health and demographic profiles.
Even if the laboratory studies aren’t conclusive, there is some real-world evidence that mild COVID infections can throw the immune system out of whack. The latest is a large observational studyon a preprint server just last week by German researchers. At first glance, the findings are scary—they found a whopping 43 percent increase in the onset of autoimmune disease in COVID patients compared with noninfected controls. But it’s important to put that number in context.
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