- The Vanguard Group, Inc.: Horizon Therapeutics plc

DJ Form 8.3 - The Vanguard Group, Inc.: Horizon Therapeutics plc The Vanguard Group, Inc. (IRSH) Form 8.3 - The Vanguard Group, Inc.: Horizon Therapeutics plc 04-Sep-2023 / 12:42 GMT/BST=----------------------------------------------------------------------------------------------------------------------

The Vanguard Group, Inc. Form 8.3 04-Sep-2023 / 12:42 GMT/BST =---------------------------------------------------------------------------------------------------------------------- Ap27 FORM 8.3 IRISH TAKEOVER PANEL OPENING POSITION DISCLOSURE/DEALING DISCLOSURE UNDER RULE 8.3 OF THE IRISH TAKEOVER PANEL ACT, 1997, TAKEOVER RULES, 2022 BY PERSONS WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE 1. KEY INFORMATION a. Full name of discloser The Vanguard Group, Inc. b.

Class of relevant security USUSD0.0001 ordinary shares Interests Short positions Number % Number % 1. Relevant securities owned and/or controlled 21,610,062 9.44% 2. Cash-settled derivatives 3. Stock-settled derivatives and agreements to purchase/ sell Total 21,610,062 9.44% All interests and all short positions should be disclosed.

Class of Product Exercising/ Exercise relevant description exercised Number of price per security e.g. call against securities unit option Other dealings 4.

Is a Supplemental Form 8 attached? No Date of disclosure 04 September 2023 Contact name Shawn Acker Telephone number 001-610-669-6713 Public disclosures under Rule 8.3 of the Rules must be made to a Regulatory Information Service.

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