What's the correlation?
The mental stimulation of a job that demands a lot of thinking and decision-making may be linked to lower levels of three proteins that prevent brain cells from forming new connections. — Filepic
So an international team of researchers set out to examine the association between cognitively-stimulating work and subsequent risk of dementia, and to identify protein pathways for this association. After adjusting for potentially influential factors, including age, sex, educational attainment and lifestyle, the risk of dementia was found to be lower for participants with high, compared with low, cognitive stimulation at work.In the low-stimulation group, it occurred at a rate of 7.3 per 10,000 person years.
This was an observational study, so can’t establish cause, and the researchers cannot rule out the possibility that some of the observed dementia risk may be due to other unmeasured factors. “The findings that cognitive stimulation is associated with lower levels of plasma proteins that potentially inhibit axonogenesis and synaptogenesis, and increase the risk of dementia, might provide clues to underlying biological mechanisms,” they conclude.
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