Recent evidence suggests that dopamine plays a crucial role in neural development. In a novel study, investigators demonstrated the link between disrupted developmental dopamine signaling and autism spectrum disorder (ASD).
May 16 2024Elsevier Recent evidence suggests that dopamine plays a crucial role in neural development. In a novel study, investigators demonstrated the link between disrupted developmental dopamine signaling and autism spectrum disorder . Their findings underscore the importance of studying developmental signaling pathways to understand the etiology of ASD, paving the way for potential targeted interventions. Their findings appear in The American Journal of Pathology , published by Elsevier.
Investigators studied the role of disrupted dopaminergic signaling in the etiology of ASD by integrating human brain RNA sequencing transcriptome analysis and a zebrafish model, recognized for its high degree of conservation with humans. To explore this link further researchers used the zebrafish model to study the effects of disrupted dopaminergic signaling on neural circuit development. They found that perturbations in developmental dopaminergic signaling led to neural circuit abnormalities and behavioral phenotypes reminiscent of autism in zebrafish larvae. The study also uncovered a potential mechanism by which dopamine impacts neuronal specification through the modulation of integrins.
Dopamine Brain Dopaminergic Education Laboratory Neuron Pathology Phenotype Research RNA RNA Sequencing
Philippines Latest News, Philippines Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Disparities in direct oral anticoagulant initiation have declined in recent years: StudyHistorical disparities in initiation of direct oral anticoagulants (DOACs) for atrial fibrillation have lessened for Black and Hispanic patients, according to a study published online May 6 in JAMA Network Open.
Read more »
Metabolomics study finds biomarkers predicting autism in newbornsA study in Communications Biology utilized metabolomics in newborns to identify markers that might predict autism spectrum disorder (ASD), finding distinct metabolic profiles in children with ASD compared to typically developing children.
Read more »
Heritability for autism spectrum disorder varies for males and females, finds studyHeritability for autism spectrum disorder (ASD) varies for males and females, with higher heritability seen for males than females, according to a study published online April 17 in JAMA Psychiatry.
Read more »
New study links autism spectrum disorder to disrupted developmental dopamineRecent evidence suggests that dopamine plays a crucial role in neural development. In a novel study, investigators demonstrated the link between disrupted developmental dopamine signaling and autism spectrum disorder (ASD).
Read more »
Recent Advances in High-Speed Atomic Force Microscopy to Improve Research Into Protein DynamicsIn this interview, AZoNano speaks with Dr. George Heath from the University of Leeds, UK, about the fundamental principles of Atomic Force Microscopy (AFM), integration with advanced optical microscopy, and relevant applications. He also discusses his research utilizing the NanoRacer.
Read more »
Liverpool boss Jurgen Klopp aims dig at Rio Ferdinand after recent interview with Man Utd legendLiverpool boss Jurgen Klopp has aimed a dig at former Manchester United defender Rio Ferdinand.
Read more »