Scientists have discovered that antibodies targeting the common amino acid transporter component CD98 heavy chain can selectively kill MultipleMyelomas in mice while leaving healthy cells intact. ScienceTM Cancer
We thank T. Yamane , K. Koh , and M. Ichii for MM samples; T. Kitamura for the retroviral vectors; and Y. Kanakura , R. Burger , and I. Weissman for the cell lines. We also thank K. Terasaki, Y. Hayami, R. Inada, M. Yamaguchi, T. Wibowo, T. Uehara, and M. Matsubara for technical assistance. Editorial services were provided by N. R. Gough .
performed the in vitro and in vivo experiments to examine the anti-MM effect of R8H283. S.Y., M.M, H.I., A.M., Y.A., T. Nakao, A.H., M.H., T. Nakagawa, N.K., H.K., A. Ikeda, T.O., Y.S., and T.K. provided human samples and datasets that were used to examine R8H283 reactivity in those samples using flow cytometry and immunohistochemistry. S. Ueda, T. Masuko, S. Nagamori, D.M., and K.Y. performed experiments to characterize the epitope recognized by R8H283. K.T., K.A., and Y.K.