Scientists have identified a potential driver of aggressive lung cancer tumors in patients who live in areas with high levels of violent crime.
University of Illinois at Urbana-ChampaignJun 24 2024 Their study found that stress responses differ between those living in neighborhoods with higher and lower levels of violent crime, and between cancerous and healthy tissues in the same individuals.
The researchers first assessed patterns of gene expression in lung cancer tumors and in cancer-free lung tissue from patients who lived in various Chicago zip codes -; some with higher or lower levels of violent crime. The team also determined where the glucocorticoid receptors were binding on DNA in those tissues.
In terms of the genes the receptors regulated in the tumors of individuals living in high-violence areas, they were genes related to inflammation, higher proliferation, higher growth-factor signaling, all of which will lead to the worst outcomes for lung cancer.
Lung Cancer Chronic Cortisol Food Gene Genes Glucocorticoid Health Disparities Inflammation Nutrition Poverty Public Health Receptor Research Stress Tumor
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