New research suggests that redefining fatigue, and understanding how a brain region known as the cerebellum processes fatigue, may hold clues for better treatment.
by Pablo Celnik and his colleagues at Johns Hopkins University shows that performance fatigue, also known as “fatigability” — an objective measurement of a person’s ability to do a physical or cognitive task — can be different from the perception of fatigue — a person’s subjective assessment of the fatigue they feel.
Fatigue is “a very significant, common problem in patients with neurological conditions,” but “it is very poorly understood,” said Once the force that they were exerting dropped below 40 percent of their baseline, they were told to stop, and then they were asked how fatigued they felt. Participants were next asked to complete a hand coordination task. People who reported less fatigue from the earlier force task had less accurate coordination; those who said they felt more fatigue were more accurate.The hand coordination movement was designed to test motor control of the participants in light of their perceived fatigue. The movement itself was not physically fatiguing.
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