A transmission electron micrograph shows SARS-CoV-2 virus particles isolated from a patient. Recently, several research teams have honed in on potential hallmarks of long COVID, formally known as post-COVID-19 condition, offering insight into the possible mechanisms at play.
For several years, scientists have tried to untangle one of COVID-19's persistent puzzles: Why do some people, even after mild infections, go on to develop lasting health issues? Now, fresh clues are emerging.A transmission electron micrograph shows SARS-CoV-2 virus particles isolated from a patient. Research teams have recently honed in on potential hallmarks of long COVID, offering insight into the possible mechanisms at play.
The team was surprised to find that some people with long COVID still had virus fragments lingering in their guts, long after they were no longer testing positive for the virus. Those particles, located through stool samples, might be enough to trigger the release of interferons.Doctors and epidemiologists are reporting a surge of new COVID infections. But Canada's rollout of the latest variant-targeting vaccines is only just beginning, and won't be in full swing for weeks.
The team found differences in blood samples that distinguished long COVID patients from the others, including exhausted immune cells and lower levels of cortisol, a hormone that regulates a wide variety of bodily processes including metabolism and immune response.Iwasaki's team also noticed the reactivation of dormant Epstein-Barr virus in long COVID patients.
Schaffner and others are hopeful, however, that these kinds of emerging findings could eventually lead to a diagnostic test for long COVID, or to potential treatments.The study zeroing in on serotonin, for instance, points to existing medications — selective serotonin reuptake inhibitors , a class of drugs most commonly prescribed to treat depression — as one area for future research.
Long COVID was linked more often to dizziness and issues with someone's sense of taste or smell, for instance, while lingering symptoms after a cold were more likely to include gastrointestinal issues.
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