The complex shape of respiratory syncytial virus is one hurdle limiting the development of treatments for an infection that leads to hospitalization or worse for hundreds of thousands of people in the United States each year, according to the Centers for Disease Control and Prevention.
New images of the virus may hold the key to preventing or slowing RSV infections. RSV is of greatest concern in young children, the elderly and adults.
The virus's structure -- which consists of tiny, bending filaments -- have eluded researchers. This has made it difficult to identify key drug targets, including viral components that are conserved across related viruses. Wright's recent study produced high-resolution images detailing the structure of two RSV proteins, RSV M protein and RSV F protein, that are crucial to the interaction between the virus and the host cell membrane. Both proteins are also present in related viruses.
The scientists believe that F protein pairs may be a key to destabilizing the virus before it is ready to infect its next host, making pairs of F proteins a possible target for future drug development. They will continue to explore how RSV proteins interact with each other to cause infection.Bryan S. Sibert, Joseph Y. Kim, Jie E. Yang, Zunlong Ke, Christopher C. Stobart, Martin L. Moore, Elizabeth R. Wright.
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