Researchers have developed a new genomic technique that can track the spread of multiple superbugs in a hospital simultaneously, which could help prevent and manage common hospital infections quicker and more effectively than ever before.
Wellcome Trust Sanger InstituteAug 20 2024
They discovered that each ICU patient tested in the study was colonised by at least one such treatment-resistant bacteria, while the majority were colonized by several of them simultaneously. As an added challenge for healthcare providers, some of these bacteria are antibiotic-resistant . Infections caused by AMR bacteria are a major issue in hospitals, with these treatment-resistant bacteria predicted to cause more deaths than cancer by 20501. While some hospitals test for AMR bacteria on arrival, no system effectively tracks all multi-drug resistant bacteria throughout a hospital.
In this new study from the Wellcome Sanger Institute, the University of Oslo, Fondazione IRCCS Policlinico San Matteo in Italy, and collaborators, the team developed a new approach that captured whole genome sequencing data across multiple pathogens at once. This is known as a 'pan-pathogen' deep sequencing approach and can provide genomic data as rapidly as hospitals can process the samples.
The team effectively mapped the spread of hospital bacteria across a 5-week sampling timeframe, allowing them to also predict which bacteria were most likely to appear in infections acquired while in the hospital.
Hospital Antibiotic Cancer Covid-19 Evolution Genome Genomic Genomics Healthcare Immune System Infectious Diseases Intensive Care Pandemic Pathogen Research Whole Genome Sequencing
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