Early detection of Alzheimer's disease-related changes in Parkinson's disease and dementia with Lewy bodies could be made possible by monitoring the amyloid-β (Aβ) and phosphorylated tau (p-tau) proteins.
Nagoya UniversityJul 31 2024 Early detection of Alzheimer's disease-related changes in Parkinson's disease and dementia with Lewy bodies could be made possible by monitoring the amyloid-β and phosphorylated tau proteins. Researchers at Nagoya University in Japan also discovered the blood levels of neurofilament light chain protein is elevated at an early stage of Parkinson's disease and dementia with Lewy bodies .
Recently, researchers have directed their attention toward the early stage of these diseases, called the prodromal stage. During the prodromal stage, abnormal protein buildup begins, leading to the eventual development of the disease about 10-20 years after the onset of motor and cognitive symptoms.
Changes in the expression of proteins Aβ and p-tau were observed in patients with PD dementia and DLB, but not in those in the prodromal stage. On the other hand, both individuals in the prodromal stage and those suffering from the diseases exhibited elevated levels of NfL.
Alzheimer's Disease Antibody Dementia Lewy Bodies Neurodegeneration Parkinson's Disease Pathology Protein
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