\u0027It\u0027s a tremendous step forward in immunotherapy\u0027
Paul Burton, Moderna’s chief medical officer, said in a separate interview the combination “has the capacity to be a new paradigm in the treatment of cancer.”
In October, Merck exercised an option to jointly develop and commercialize the treatment, known as mRNA-4157/V940, sharing costs and any profits equally. Merck and Moderna plan to discuss the results with regulatory authorities and start a Phase III study in melanoma patients in 2023.Article content To build the vaccine, researchers took samples of patients’ tumours and healthy tissue. After analyzing the samples to decode their genetic sequence and isolate mutant proteins associated only with the cancer, that information was used to design a tailor-made cancer vaccine.Article content
Barr said the companies intend to study the approach in other types of highly mutated cancers, such as lung cancer. Other highly mutated cancers include bladder cancers and some triple negative breast cancers. Experts said the personalized vaccines were among several promising cancer vaccine ideas in the works after many failures in the field.
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