The drug ketamine has a reputation as a psychedelic party drug, but in lower doses it's been shown to bring remarkable relief to severe cases of depression. Scientists think it helps restore synapses in the brain that are destroyed by stress. | CBCQuirks
Ketamine relieves depression by restoring damaged neural connectionsThe anaesthetic drug ketamine might have a reputation as a psychedelic party drug, but in lower doses it's been shown to bring remarkable — almost immediate — relief to severe and otherwise untreatable cases of depression. And now scientists think they know why: it helps restore synapses in the brain that are destroyed by stress.
What is striking is that we also saw, like other researchers, a very important effect — almost everybody experiences a decrease in suicidal ideation. And that's the major impact."What is striking is that we also saw, like other researchers, a very important effect — almost everybody experiences a decrease in suicidal ideation," said Blier. "And that's the major impact."
"This investigation into ketamine is actually part of a larger project underway in my lab where we're trying to understand the mechanisms that mediate transitions between depressive episodes," said Liston. He's the senior author of aPaxil is a seratonin-based antidepressant that can cause the worrying side effect of inducing thoughts of suicide. Whereas ketamine has been shown to reduce suicidal thoughts.Depression is not just bad for the mind, it's bad for the brain.
What we found is that those new connections are really important for stabilizing the brain in a 'well state.'Ketamine works on the brain's glutamate neurotransmitter, which is involved in communicating between nerve cells. The researchers think this is what provides the immediate effects of relief, which then becomes reinforced with the formation of new synapses.
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