Late-breaker data presented at the annual American Academy of Dermatology meeting show that IL-17 and IL-23 inhibitors achieve sustained clear or almost clear responses in patients with moderate to severe plaque psoriasis.
In a 4-year open-label extension study, the Psoriasis Area and Severity Index (PASI) 90 rate was approximately 85% in treated patients, according to professor and chairman emeritus of the Department of Dermatology, Icahn School of Medicine at Mount Sinai in New York City. The proportion of patients who achieved a PASI 100 score, signifying total clearance, approached 70% at 4 years in the group with the greatest response.
PASI 90 and PASI 100 rates at this point were only modestly lower than those reported at the end of the double-blind phase 3 trial when evaluated 3 years earlier
Psoriasis IL-17 Inhibitor IL-23 Inhibitor Response Rates Sustained Clinical Trial
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