A combination of estrogen and progesterone given during the follicular phase of the menstrualcycle significantly reduced the level of hormones needed for effective contraception, based on data from a new mathematical model. ObGynTwitter
, progesterone , and inhibin , in a normal cycle. In the model, LH, FSH, and E2 peaked in the late follicular phase, and P4 and Inh peaked in the luteal phase.
The researchers then assessed the impact of time on dosage. They found that estrogen administration starting on the first day of a normal cycle preventing FHS from reaching maximum value, and that the low level of FHS in the follicular phase and additional P4 inhibition slowed follicular growth, and use of combination estrogen/progesterone caused similar inhibition at a later follicular stage.
The findings were limited by the use of a standard model that does not account for variations in cycle length, the researchers noted. However, the results reflect other studies of hormonal activity, and the model can be used in future studies of the effect of hormones on cycle length, they said. Ms. Gavina said that she was surprised primarily by the optimal control result for estrogen monotherapy."It was surprising that, theoretically, our mathematical model, with the simplifying assumptions, showed that as low as 10% of the total dose in constant administration could achieve contraception as long as the administration of this dosage is perfectly timed, and the timing was also shown in our optimization result," she said.
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