COVID-19 rebound after Pfizer treatment likely due to robust immune response, study finds

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COVID-19 rebound after Pfizer treatment likely due to robust immune response, study finds
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Patients in the study had developed robust immune responses, but researchers found higher levels of antibodies in the patients who experienced a rebound

A rebound of COVID-19 symptoms in some patients after taking Pfizer’s antiviral Paxlovid may be related to a robust immune response rather than a weak one, U.S. government researchers reported on Thursday.

The team said their data argues against the hypothesis that impaired immune responses are the reason symptoms return in some patients. President Joe Biden and National Institute of Allergy and Infectious Diseases Director Dr. Anthony Fauci both experienced aThe cases raised concerns that Pfizer’s two-drug antiviral treatment could interfere with development of a long-lasting immune response.

All of the rebound patients had experienced significant improvement in their symptoms before their rebound. Of those who had a rebound after Paxlovid, four had milder symptoms than during their initial infection, one had the same level of severity and one reported worse symptoms.Rebound symptoms may be partially driven by a robust immune response to residual virus in the respiratory tract, the study authors suggested.

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