Study finds long-term use of specific progestogens increases the risk of benign brain tumors in women, while short-term use and other progestogens do not.
By Dr. Chinta SidharthanApr 3 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal BMJ, a team of French researchers investigated the association between progestogen use and the risk of benign central nervous system tumors such as intracranial meningioma among women.
Female sex, neurofibromatosis type 2, and ionizing radiation exposure to the intracranial region are other known risk factors for meningiomas, apart from age. Recent research has also indicated that the long-term use of three progestogens — chlormadinone acetate, nomegestrol acetate, and cyproterone acetate — at high doses can also increase the risk of intracranial meningiomas.
The study also aimed to characterize factors such as age, location of meningioma, and tumor grade for the women included in the case group and determine how many of the meningiomas that were surgically treated could be attributed to the use of one of the progestogens. The data for this case-control study was obtained from France's national health data system.
The researchers analyzed three modes of exposure to progestogens. The first was exposure to the progestogen of concern. The second was exposure to a high dose of one of the three progestogens already associated with increased meningioma risk in the three years leading up to the index date. The third mode was the absence of exposure to any of the progestogens. The analysis also included a wide range of medical and sociodemographic factors as covariates.
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