Sun Health Explainer: Dementia and Alzheimer’s disease
In the past, human neurological healthcare has been limited by the difficulty of delivering targeted treatment across the blood-brain-barrier and into the correct location inside neurons.
The potential to use engineered brain parasites to deliver treatment across the blood-brain-barrier was described as "pioneering" and a global breakthrough - although it is still years away from becoming reality.The study team first had to find out whether they could effectively make the parasites produce the therapeutic proteins, and then test whether the parasites would be able to "spit" the proteins back out into affected brain cells.
The parasite successfully produced the protein, and then delivered it to the target cell location in brain organoids and in mice models. Professor Lilach Sheiner, one of the leading authors of the study from the University of Glasgow's School of Infection and Immunity, said: "This is a blue-sky project where our collaborative team was thinking out of the box to try to tackle the long-standing medical challenge of finding a way to successfully deliver treatment to the brain for cognitive disorders.
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