The potential of nano-formulations to boost the bioavailability and bioactivity of curcumin.
By Dr. Sushama R. Chaphalkar, PhD.Mar 12 2024Reviewed by Lily Ramsey, LLM In a recent review published in the journal Antioxidants, researchers explored the potential of nano-formulations to boost the bioavailability and bioactivity of curcumin and its metabolites to amplify their antioxidant properties and disease-preventing effects potentially.
Various nano-formulations have been developed to address curcumin's bioavailability limitations, aiming to enhance its stability and uptake. Curcumin's bioavailability varies significantly, with plasma concentrations ranging from nanomolar to microgram levels. Factors like dose, duration, and mode of administration influence bioavailability across species.
Related StoriesThese formulations show promising outcomes in preclinical studies, with increased bioavailability, cellular uptake, blood-brain barrier permeability, and tissue distribution. Nano-formulations enhance antimicrobial potential, while curcumin-microbiota interaction supports intestinal health and reduces inflammation.
Curcumin exhibits therapeutic potential for liver diseases, demonstrating anti-inflammatory, antioxidant, and anti-fibrotic effects. Clinical trials suggest positive effects of curcumin on body weight, body fat, and metabolic markers in overweight/obese individuals, as well as in the prevention of cardiovascular diseases. Further research in clinical settings is warranted to optimize curcumin's anti-inflammatory effects in human chronic inflammation.
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