COVID patients who received the drug half as likely to be admitted to hospital or to visit an ER than those given a placebo, clinical trial results show
An antiviral drug that is administered in a single shot could be an effective addition to the available treatments for COVID-19, particularly for high-risk patients, a new study has found.
Unlike Paxlovid, which is taken as a combination of tablets, interferon lambda has very few drug interactions, Dr. Feld said. So for people who can’t take Paxlovid while they’re on other medications, or who have trouble taking pills, “this would be a particularly good option,” he said. While there are different types, Dr. Feld and his colleagues focused on interferon lambda, a Type III interferon. Unlike interferon alpha, a Type I interferon that has been used for treating hepatitis C and attaches to a receptor found on cells throughout the body, interferon lambda attaches to receptors on cells that exist only in limited places in the body, particularly the lung, liver and the intestine.
Within seven days of their first COVID symptoms, 933 patients were assigned to receive interferon lambda, and 1,018 were given a placebo. A total of 25 patients in the interferon group required hospital admission or an emergency visit, compared with 57 in the placebo group., led by Dr. Feld, showed that interferon lambda shortened the duration of a COVID infection.
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