Researchers have used artificial intelligence techniques to massively accelerate the search for Parkinson's disease treatments.
Apr 17 2024University of Cambridge Research ers have used artificial intelligence techniques to massively accelerate the search for Parkinson's disease treatments.
Parkinson's affects more than six million people worldwide, with that number projected to triple by 2040. No disease-modifying treatments for the condition are currently available. The process of screening large chemical libraries for drug candidates – which needs to happen well before potential treatments can be tested on patients – is enormously time-consuming and expensive, and often unsuccessful.
Proteins are responsible for important cell processes, but when people have Parkinson's, these proteins go rogue and cause the death of nerve cells. When proteins misfold, they can form abnormal clusters called Lewy bodies, which build up within brain cells stopping them from functioning properly. This has been a major obstacle in Parkinson's research, because of the lack of methods to identify the correct molecular targets and engage with them. This technological gap has severely hampered the development of effective treatments.
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